| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Epigallocatechin gallate (PubChem CID: 65064 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | TNFRSF10B | hsa8795 |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| Result | Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors | |||
| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | PEA15 | hsa8682 |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| A-172 | Glioblastoma | Homo sapiens (Human) | CVCL_0131 | |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| Result | Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma | |||
| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Expression | TNFRSF10A | hsa8797 | |
| In Vitro Model | A-375 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_0132 |
| Result | EGCG enhances TRAIL-mediated apoptosis in human melanoma A375 cell line | |||
| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| In Vitro Model | MIA PaCa-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0428 |
| Result | Combination of epigallocatechin-3-gallate and TRAIL synergistically increase the apoptosis and cleavage of procaspase-3 in pancreatic cancer cells | |||
| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2B6B] | Nasopharyngeal carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Down-regulation | Expression | CDH13 | hsa1012 | |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Down-regulation | Expression | FADD | hsa8772 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | CNE-1 | Nasopharyngeal carcinoma | Homo sapiens (Human) | CVCL_6888 |
| CNE-2 | Nasopharyngeal carcinoma | Homo sapiens (Human) | CVCL_6889 | |
| C666-1 | Nasopharyngeal carcinoma | Homo sapiens (Human) | CVCL_7949 | |
| NP69SV40T | Healthy | Homo sapiens (Human) | CVCL_F755 | |
| Result | EGCG sensitizes NPC cells to TRAIL-mediated apoptosis via modulation of extrinsic and intrinsic apoptotic pathways and inhibition of NF-κB activation. | |||
| Pair Name | Epigallocatechin gallate, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ANGPT1 | hsa284 |
| Down-regulation | Expression | BAD | hsa572 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC3 | hsa330 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Down-regulation | Expression | CASP3 | hsa836 | |
| Down-regulation | Expression | CASP6 | hsa839 | |
| Down-regulation | Expression | CASP8 | hsa841 | |
| Down-regulation | Expression | CASP9 | hsa842 | |
| Down-regulation | Expression | MMP2 | hsa4313 | |
| Down-regulation | Expression | MMP3 | hsa4314 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | PARP1 | hsa142 | |
| Up-regulation | Expression | TIMP1 | hsa7076 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
| Result | EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis | |||
| No. | Title | Href |
|---|---|---|
| 1 | Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors. Oncotarget. 2016 Oct 4;7(40):65660-65668. doi: 10.18632/oncotarget.11597. | Click |
| 2 | Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma. Neurosci Lett. 2008 Dec 19;448(1):161-5. doi: 10.1016/j.neulet.2008.10.036. | Click |
| 3 | EGCG enhances TRAIL-mediated apoptosis in human melanoma A375 cell line. J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):771-5. doi: 10.1007/s11596-009-0620-4. | Click |
| 4 | Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death. Int J Oncol. 2009 Jan;34(1):281-6. | Click |
| 5 | EGCG sensitizes human nasopharyngeal carcinoma cells to TRAIL-mediated apoptosis by activation NF-κB. Neoplasma. 2017;64(1):74-80. doi: 10.4149/neo_2017_109. | Click |
| 6 | Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene. 2008 Mar 27;27(14):2055-63. doi: 10.1038/sj.onc.1210840. | Click |
